Trial Updates

현재 추적 중인 미토콘드리아 임상시험 파이프라인은 총 18건입니다.

주요 임상시험 파이프라인 및 연구 동향

1. 🟢 모집 중 임상시험 (9건)

• ASCENT: Adipose Stem Cell Mitochondria Supplementation to Oocytes (Sunkaky Medical Cooperation - NCT07066267) [적응증: Female Infertility, Recurrent Implantation Failures]
• Safety and Therapeutic Effects of Autologous CD34+ Cells Enriched With Allogeneic Placenta-Derived Mitochondria in Pearson Syndrome (Minovia Therapeutics Ltd. - NCT06017869) [적응증: Mitochondrial Diseases, Pearson Syndrome]
• Transplantation of Autologously Derived Mitochondria Following Ischemia (Boston Children's ECMO trial) (Boston Children's Hospital - NCT02851758) [적응증: Extracorporeal Membrane Oxygenation Complication]
• Autologous Mitochondrial Transplant for Cerebral Ischemia (University of Washington - NCT04998357) [적응증: Cerebral Ischemia]
• Collection of Donated Placenta for Isolation of Mitochondria for Research and for Future Use in Mitochondrial Augmentation Therapies (Minovia Therapeutics Ltd. - NCT03762512) [적응증: Pregnancy Related]
• A Study to Evaluate the MNV-201 in Patients With Low Risk MDS (Minovia Therapeutics Ltd. - NCT06465160) [적응증: Myelodysplastic Syndromes]
• Phase 2 Trial to Evaluate the Efficacy, Safety of Allogeneic Mitochondria (PN-101) in Patients With Refractory Polymyositis or Dermatomyositis (Paean Biotechnology Inc. - NCT07122648) [적응증: Polymyositis, Dermatomyositis]
• Impact of Metabolite Supplementation to Restore Mitochondrial Dysfunction During Septic Shock: a Preclinical Study (University Hospital, Angers - NCT04288635) [적응증: Septic Shock, Multiple Organ Failure]
• Increasing Mitochondrial Respiration as a Novel Mechanism for Cognitive Augmentation (Francisco Gonzalez-Lima, PhD - NCT07793604) [적응증: Cognition Improvement, Emotion Regulation]

2. 🟡 진행 및 파이프라인 관찰 대상 (5건)

• Automitochondrial Transplantation Improves Live Birth in Elderly Patients With Low Prognosis After Repeated IVF Failure (Peking University People's Hospital - NCT06020742) [적응증: Infertility, Female, Elderly]
• Co-transplantation of MSC-Derived Exosomes and Autologous Mitochondria for CABG Surgery Patients (Tehran University of Medical Sciences - NCT05669144) [적응증: Myocardial Infarction, Myocardial Ischemia, Myocardial Stunning]
• Clinical Application of Autologous Mitochondria Transplantation for Improving Oocyte Quality. (Sun Yat-sen University - NCT03639506) [적응증: Repetition Failure]
• A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion (Minovia Therapeutics Ltd. - NCT04548843) [적응증: Primary Mitochondrial Diseases]
• Vitamin B12 and Folinic Acid Supplementation in Mitochondrial DNA Deletion Syndromes (University of British Columbia - NCT06186154) [적응증: Mitochondrial DNA Deletion, Macrocytosis]

3. 🔵 완료 및 임상 데이터 확보 (4건)

• Safety and Therapeutic Effects of MNV-BM-BLD Transplantation in Pediatric Pearson Syndrome (Minovia Therapeutics Ltd. - NCT03384420) [적응증: Mitochondrial Diseases, Pearson Syndrome]
• Allogeneic Mitochondria (PN-101) Transplantation for Refractory Polymyositis or Dermatomyositis (Paean Biotechnology Inc. - NCT04976140) [적응증: Polymyositis, Dermatomyositis]
• Autologous Mitochondrial Transfer in ICSI to Improve Oocyte and Embryo Quality in IVF Patients. Pilot Study (Instituto Valenciano de Infertilidad, IVI VALENCIA - NCT02586298) [적응증: Infertility]
• Niacin Supplementation in Healthy Controls and Mitochondrial Myopathy Patients (University of Helsinki - NCT03973203) [적응증: Mitochondrial Myopathies]