97b7731cgit rev-parse HEAD and compare to check if the graph is stale.graphify update . after code changes (no API cost).1. Mitochondrial transplantation therapy (MTT) - 36 edges
2. Mitochondria Transfer - 24 edges
3. Mitochondria - 12 edges
4. Tunneling Nanotubules - 12 edges
5. PCT Pending IOB MitoCatch Platform - 11 edges
6. Therapeutic mitochondria treatment amplifies macrophage-mediated phagocytosis and recycling exocytosis - 10 edges
7. Mesenchymal Stromal Cells - 9 edges
8. MitoCeption - 9 edges
9. Retinal damage promotes mitochondrial transfer in the visual system of a mouse model of Leber hereditary optic neuropathy - 8 edges
10. Macrophages - 7 edges
Nuclear Transfer --semantically_similar_to--> MitoCeption [INFERRED] [semantically similar]PMID_35064435.md → PMID_33438576.md
MitoCeption --semantically_similar_to--> Mitochondrial transplantation therapy (MTT) [INFERRED] [semantically similar]PMID_33438576.md → PMID_38703929.md
Human Mesenchymal Stem Cells --semantically_similar_to--> Mesenchymal Stem Cells [INFERRED] [semantically similar]PMID_42367078.md → PMID_37214784.md
Metabolic reprogramming and signalling networks in microglial activation: Implications for neurodegeneration --conceptually_related_to--> Mitochondrial transplantation therapy (MTT) [INFERRED]PMID_42031319.md → PMID_38703929.md
Flow Cytometric Chromosomal Sex Sorting --references--> Mitochondria [EXTRACTED]PMID_26592367.md → PMID_41072329.md
Cohesion: 0.06
Nodes (45): MCAO, Cardiomyocytes, MITO-Porter, Mitochondrial augmentation of CD34+ cells from healthy donors and patients with mitochondrial DNA disorders confers functional benefit, Oxidative stress facilitates exogenous mitochondria internalization and survival in retinal ganglion precursor-like cells, Oxidative stress and mitochondrial transfer: A new dimension towards ocular diseases, CD34+ Hematopoietic Cells, Mitochondrial Augmentation Therapy (MAT) (+37 more)
Cohesion: 0.06
Nodes (34): Fusogenic plasma membrane vesicles, Primary Human Cardiomyocytes, Mitochondrial drug delivery system (DDS), hND6T14484C, Mitochondria-rich extracellular vesicles, Intercellular Mitochondrial Transfer, Mitochondria Transfer, Mitochondria/rAAV IGF-I system (+26 more)
Cohesion: 0.1
Nodes (24): Exosomes, Mechanisms of Mesenchymal Stem/Stromal Cell Function, Microvesicles, BACH2, CD39/CD73 Signaling, FOXP3, Induced T-regulatory Cells, Mesenchymal stromal cell mitochondrial transfer to human induced T-regulatory cells mediates FOXP3 stability (+16 more)
Cohesion: 0.1
Nodes (22): Oxidative stress, Flow Cytometric Chromosomal Sex Sorting, Equine semen, MSTN genotype, Apoptosis, Mitochondrial Autophagy, Mitochondrial Fission, Myocardial Ischemia-Reperfusion Injury (+14 more)
Cohesion: 0.12
Nodes (21): Cell-type-targeted mitochondrial transplantation rescues cell degeneration, MitoCatch, Zero-Valent-Iron Nanoparticle, Arg1, Astrocytes, Cd163, Microglia, Neurite Extension (+13 more)
Cohesion: 0.16
Nodes (18): Bispecific nanobody platform for targeted organelle and protein conjugate intracellular delivery, Erythrocyte-membrane-vesicle-encapsulated mitochondria delivery system (Mito-EMVs), Multivalent and multispecific single domain antibody polypeptides, Apparatus and methods for local micro-injection and delivery of isolated mitochondria to myocardial tissue, Human stem cells enriched with functional exogenous mitochondria and therapeutic uses thereof (MAT Platform), Mitochondrial augmentation therapy of muscle diseases, metabolic disorders, and Pearson syndrome, PCT Pending IOB MitoCatch Platform, Pharmaceutical composition comprising isolated allogeneic mitochondria for treating inflammatory and autoimmune diseases (PN-101) (+10 more)
Cohesion: 0.18
Nodes (12): Mitochondrial Transplantation Attenuates Airway Hyperresponsiveness by Inhibition of Cholinergic Hyperactivity., Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation., Artificial Mitochondrial Transfer (AMT) for the Management of Age-related Musculoskeletal Degenerative Disorders: An Emerging Avenue for Bone and Cartilage Metabolism Regulation., An Engineered Hierarchical Hydrogel with Immune Responsiveness and Targeted Mitochondrial Transfer to Augmented Bone Regeneration., a127/mito@ZIF@Ma, Biomimetic MOF Nanocarrier-Mediated Synergistic Delivery of Mitochondria and Anti-Inflammatory miRNA to Alleviate Acute Lung Injury, Umbilical mesenchymal stem cells mitigate T-cell compartments shift and Th17/Treg imbalance in acute ischemic stroke via mitochondrial transfer., Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation (+4 more)
Cohesion: 0.25
Nodes (11): SIMR Cells, MitoCeption, MitoPunch, mtDNA, Stable Isolated Mitochondrial Recipient Cells, Stable transplantation of human mitochondrial DNA by high-throughput, pressurized isolated mitochondrial delivery, Nuclear Transfer, AMP-activated protein kinase (AMPK) (+3 more)
Cohesion: 0.28
Nodes (9): Cytoplasmic transfer in oocytes: biochemical aspects., Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome., Causes of and Solutions to Mitochondrial Disorders: A Literature Review., Pretargeted Mitochondrial Delivery of Organoarsenicals for Cancer Immunotherapy., Kidney transplantation in mitochondrial diseases: a systematic review., Mitochondrial transfer: A novel mechanism and promising therapeutic strategy in ageing kidney., Targeting the powerhouse: the mitochondrial perspective on gentamicin-induced kidney injury., Emerging therapeutic strategies for mitochondrial DNA-related diseases. (+1 more)
Cohesion: 0.22
Nodes (9): Equine Metabolic Syndrome Affects Viability, Senescence, and Stress Factors of Equine Adipose-Derived Mesenchymal Stromal Stem Cells: New Insight into EqASCs Isolated from EMS Horses in the Context of Their Aging, 5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating Autophagy, Optimizing beta cell function through mesenchymal stromal cell-mediated mitochondria transfer, Mitochondrial surface coating with artificial lipid membrane improves the transfer efficacy, Rescuing cellular function in Fuchs endothelial corneal dystrophy by healthy exogenous mitochondrial internalization, Investigation of the Nanoparticulation Method and Cell-Killing Effect following the Mitochondrial Delivery of Hydrophobic Porphyrin-Based Photosensitizers, Artificial mitochondrial transplantation (AMT) reverses aging of mesenchymal stromal cells and improves their immunomodulatory properties in LPS-induced synoviocytes inflammation, Mitochondria-Targeted MPDA Nanosystem Co-Delivering Evodiamine and IR820 for Chemo-Photothermal Therapy of Hepatocellular Carcinoma (+1 more)
Cohesion: 0.22
Nodes (9): Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation., Photoreceptor nanotubes mediate the in vivo exchange of intracellular material., Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications., Mitochondrial transfer drives immune evasion in tumor microenvironment., Mitochondrial transfer in endothelial cells and vascular health., Tumor-to-endothelium mitochondrial transfer licenses endothelial cells for CD8+ T cell recognition via mitochondrial neoantigen presentation., Mitochondrial transfer in sepsis: Dual role, mechanistic networks, and translational strategies., Mitochondrial extracellular vesicles between pathology and regeneration. (+1 more)
Cohesion: 0.25
Nodes (8): Transplantation of autologously derived mitochondria protects the heart from ischemia-reperfusion injury, Delivery of mitochondria confers cardioprotection through mitochondria replenishment and metabolic compliance, Mitochondrial transplantation reduces lower limb ischemia-reperfusion injury by increasing skeletal muscle energy and adipocyte browning, Mitochondrial transfer in the progression and treatment of cardiac disease, Mitochondrial Transplantation: A Novel Therapy for Liver Ischemia/Reperfusion Injury, Mitochondrial dysfunction in AMI: mechanisms and therapeutic perspectives, From preservation to repair: Mitochondrial transplantation as a paradigm shift in organ transplantation, Circulating Mitochondrial Transfer Carrying Dihydroorotate Dehydrogenase Reduces Oxidative Cell Death in Prolonged Cold-induced Cardiac Reperfusion Injury in Heart Transplantation
Cohesion: 0.25
Nodes (8): Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits, Mitochondrial transplantation: an overview of a promising therapeutic approach, Post-acute ischemic stroke hyperglycemia aggravates destruction of the blood-brain barrier., Mitochondrial transplantation: a promising strategy for treating degenerative joint diseases., Triphenylphosphonium-functionalised cubosomes for mitochondrial-targeted delivery of 5-fluorouracil and lycopene in skin cancer therapy., Mitochondria-Associated mRNAs Restore ATP During Oxidative Stress via Cytosolic Translation., Lipid droplets-mediated delivery of curcumin for targeted mitochondrial photodynamic therapy., Mitochondrial dysfunction-driven PANoptosis in doxorubicin-induced cardiotoxicity: mechanistic insights and intervention strategies.
Cohesion: 0.33
Nodes (6): Mesenchymal stem cell-mediated transfer of mitochondria: mechanisms and functional impact, Mechanisms of Mitochondrial Transfer Through TNTs: From Organelle Dynamics to Cellular Crosstalk, The role of mitochondrial transfer in lung disease, Therapeutic and mechanistic insights on mitochondrial transplantation in kidney disease, Mitochondrial dynamics and transfer in mesenchymal stromal cells: Redox regulation, therapeutic mechanisms, and engineering strategies, Intercellular Mitochondrial Transfer as Endogenous Neuroprotection: Mechanisms and Therapeutic Implications in Ischemic Stroke
Cohesion: 0.33
Nodes (6): Mitochondrial therapeutics, Stroke, Nanomedicines, cGAS/STING, Mitochondrial dysfunction, Ischemic heart disease
Cohesion: 0.33
Nodes (6): Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy, Allogeneic human umbilical cord Wharton's jelly stem cells increase several-fold the expansion of human cord blood CD34+ cells both in vitro and in vivo, Mitochondria and the Tumour Microenvironment in Blood Cancer, A tumor-derived mitochondrial tsRNA drives vascular invasion of lung adenocarcinoma by promoting ribosomal assembly in endothelial cells, The RAC1 tripartite hub: coupling metabolic plasticity and immune evasion to dictate breast cancer cell fate, Altered Complement and Tubular Mitochondrial Proteins Are Linked to Graft Loss in DSA+ Antibody-Mediated Rejection
Cohesion: 0.4
Nodes (5): Pre-Clinical Drug Testing in 2D and 3D Human In Vitro Models of Glioblastoma Incorporating Non-Neoplastic Astrocytes: Tunneling Nano Tubules and Mitochondrial Transfer Modulates Cell Behavior and Therapeutic Respons, Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease, Melatonin reshapes the mitochondrial network and promotes intercellular mitochondrial transfer via tunneling nanotubes after ischemic-like injury in hippocampal HT22 cells, Mechanisms of electroacupuncture-induced neuroprotection in acute stroke rats: the role of astrocyte-mediated mitochondrial transfer, Exogenous mitochondrial transfer alleviates neurodegeneration in Parkinson's disease model by improving mitochondrial function
Cohesion: 0.4
Nodes (5): Therapeutic mitochondrial transfer via mesenchymal stem cell-derived microvesicles for macrophage modulation in myocardial infarction complicated by diabetes, Vesicle-guided mitochondria: A new perspective for brain mitochondrial transplantation, Reparative "exosome-ark" for mitochondrial transplantation to reprogram macrophages and disrupt pathogenic crosstalk in pulmonary fibrosis, The Role of Perivascular Stem Cells in Inflammatory Vascular Diseases: From Immunomodulation to Vascular Regeneration, Sarcopenia and sepsis fuel a self-perpetuating cycle of immunometabolism decline
Cohesion: 0.4
Nodes (5): M2 macrophage-derived mitochondrial transplantation promotes periodontal bone regeneration by regulating metabolic homeostasis via activating p38-MAPK signaling pathway, Bone-targeted mitochondrial delivery via magnetic-temperature responsive artificial cells for repairing age-related fractures, Light-Activated Isolation of High-Quality Mitochondria for Therapeutic Transplantation, Transplantation of AQP1-overexpressing mitochondria attenuates periodontitis-associated bone loss by regulating mitochondria-ER contacts of macrophages, Optimized Isolation and Cryopreservation of Functional Mitochondria for Transplantation and Therapeutic Applications
Cohesion: 0.5
Nodes (4): Submaximal exercise training improves mitochondrial efficiency in the gluteus medius but not in the triceps brachii of young equine athletes, 5-Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy, Effects of hyperthermia and acidosis on mitochondrial production of reactive oxygen species, Thoroughbred horses susceptible to recurrent exertional rhabdomyolysis have elevated skeletal muscle mitochondrial capacities
Cohesion: 0.5
Nodes (4): Camptothecin (CPT), Mitochondrial Targeting, Polycaprolactone (PCL), Triphenylphosphonium (TPP+)
Cohesion: 0.5
Nodes (4): Oral mitochondrial transplantation using nanomotors to treat ischaemic heart disease, Comparative analysis of mitochondrial and mesenchymal stem cell transplantation for angiogenesis and muscle regeneration, Mitochondrial Transplantation Augments the Reparative Capacity of Macrophages Following Myocardial Injury., Sequential Mitochondrial Transplantation for Myocardial Ischemia-Reperfusion Injury Treatment.
Cohesion: 0.67
Nodes (3): Inhibition of Mitochondrial Complex I Leads to Decreased Motility and Membrane Integrity Related to Increased Hydrogen Peroxide and Reduced ATP Production, while the Inhibition of Glycolysis Has Less Impact on Sperm Motility., Lactate and Pyruvate Are Major Sources of Energy for Stallion Sperm with Dose Effects on Mitochondrial Function, Motility, and ROS Production., Low glucose and high pyruvate reduce the production of 2-oxoaldehydes, improving mitochondrial efficiency, redox regulation, and stallion sperm function†.
Cohesion: 0.67
Nodes (3): Metformin Increases Proliferative Activity and Viability of Multipotent Stromal Stem Cells Isolated from Adipose Tissue Derived from Horses with Equine Metabolic Syndrome, Altered Metabolic Phenotype of Immune Cells in a Spontaneous Autoimmune Uveitis Model, Enhanced ROS Production and Mitochondrial Metabolic Shifts in CD4+ T Cells of an Autoimmune Uveitis Model
Cohesion: 0.67
Nodes (3): Aerobic Respiration, Endocytosis-mediated Mitochondrial Transplantation, Glioma Cells
Cohesion: 0.67
Nodes (3): Sperm mitochondrial regulation in motility and fertility in horses., High-Resolution Fluoro-Respirometry of Equine Skeletal Muscle., Metformin and rosiglitazone affect motility, lipid peroxidation and mitochondrial activity of thawed equine spermatozoa.
Cohesion: 0.67
Nodes (3): Mitochondrial transplantation ameliorates ischemia/reperfusion-induced kidney injury in rat, Therapeutic potential of mitochondrial transplantation in modulating immune responses post-cardiac arrest: a narrative review, Mitochondrial transplantation attenuates alveolar epithelial cell dysfunction and reduces disruption of tight junction proteins to alleviate lung ischaemia-reperfusion injury
Cohesion: 0.67
Nodes (3): Glucose, In Vitro Maturation, Stallion Spermatozoa
Cohesion: 0.67
Nodes (3): Transplantation of MITO cells, mitochondria activated cardiac progenitor cells, to the ischemic myocardium of mouse enhances the therapeutic effect., Neuroprotective effect of autologous mitochondrial transplantation against global ischemia/reperfusion injury in a rat model of cardiac arrest., Hypoxia-preconditioned mitochondrial transplantation multidirectionally modulates Schwann cell functions to repair peripheral nerve injury in rats.
Cohesion: 0.67
Nodes (3): Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss, Targeted Mitochondrial Delivery to Hepatocytes: A Review, A nose-to-brain drug delivery system targeting mitochondrial dysfunction: application potential and future prospects of chitosan nanogels in Alzheimer's disease
Cohesion: 0.67
Nodes (3): Astaxanthin Carotenoid Modulates Oxidative Stress in Adipose-Derived Stromal Cells Isolated from Equine Metabolic Syndrome Affected Horses by Targeting Mitochondrial Biogenesis, Analysis of stallion spermatozoa metabolism using Agilent Seahorse XFp Technology, Revitalizing equine metabolism: how SHBG improves mitochondrial function and reduces inflammation
Cohesion: 0.67
Nodes (3): Mitochondrial Bioenergetics at the Onset of Drug Resistance in Hematological Malignancies: An Overview, M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and improving mitochondrial metabolism, Thymosin β4 Regulates the Differentiation of Thymocytes by Controlling the Cytoskeletal Rearrangement and Mitochondrial Transfer of Thymus Epithelial Cells
Cohesion: 0.67
Nodes (3): FOXQ1, hnRNPA2B1, miR-320a-3p
Cohesion: 0.67
Nodes (3): Decellularized Adipose Tissue Hydrogel, Mitochondria Transplanted Adipose-Derived Stem Cells, Mito-ADSCs/DAT Hydrogel
Cohesion: 0.67
Nodes (3): Intranasal mitochondrial transplantation, Mitochondrial-Astrocyte-Neuron Triad Hypothesis, Parkinson's Disease
Cohesion: 0.67
Nodes (3): Transcriptomic and proteomic pathways of diabetic and non-diabetic mitochondrial transplantation, Correction to "Effect of Umbilical Cord Mesenchymal Stem Cell-Derived Mitochondrial Transplantation on Ischemia-Reperfusion Injury in a Rat Model", Mitochondrial Transplantation as a New Therapeutic Approach Against Cardiac and Renal Consequences in Male Rats With Myocardial Infarction
Cohesion: 0.67
Nodes (3): KG-1a, Cx43, PGC-1α
Cohesion: 0.67
Nodes (3): RNA Delivery to Mitochondria, GTPBP3, 5-Methoxyuridine (mo5U)
Correction to "Effect of Umbilical Cord Mesenchymal Stem Cell-Derived Mitochondrial Transplantation on Ischemia-Reperfusion Injury in a Rat Model" → Mitochondrial Transplantation as a New Therapeutic Approach Against Cardiac and Renal Consequences in Male Rats With Myocardial Infarction [AMBIGUOUS]PMID_41318219.md · relation: references
Ischemic Stroke, Glioma Cells, Aerobic Respiration, Microvesicles, Huayu Tongluo Moxibustion (+251 more)These have ≤1 connection - possible missing edges or undocumented components.
graphify query to explore isolated nodes._Questions this graph is uniquely positioned to answer:_
Correction to "Effect of Umbilical Cord Mesenchymal Stem Cell-Derived Mitochondrial Transplantation on Ischemia-Reperfusion Injury in a Rat Model" and Mitochondrial Transplantation as a New Therapeutic Approach Against Cardiac and Renal Consequences in Male Rats With Myocardial Infarction?_Edge tagged AMBIGUOUS (relation: references) - confidence is low._
Mitochondria Transfer connect Autologous Mitochondrial Transplant Trials to Mitochondrial Biology Core, Cardiac Ischemia-Reperfusion Therapy, Daily Collector Pipeline, cf-mtDNA DAMPs & cGAS-STING?_High betweenness centrality (0.082) - this node is a cross-community bridge._
Mitochondrial transplantation therapy (MTT) connect Mitochondrial Biology Core to Autologous Mitochondrial Transplant Trials, Daily Collector Pipeline, Bone & Vascular Regeneration, cf-mtDNA DAMPs & cGAS-STING, Reproductive Mitochondrial Transfer?_High betweenness centrality (0.078) - this node is a cross-community bridge._
Tunneling Nanotubules connect Cardiac Ischemia-Reperfusion Therapy to Mitochondrial Biology Core, Autologous Mitochondrial Transplant Trials, Bone & Vascular Regeneration?_High betweenness centrality (0.031) - this node is a cross-community bridge._
Mitochondrial transplantation therapy (MTT) (e.g. with Platelet-derived mitochondrial transplantation and Mitochondrial dysfunction) actually correct?_Mitochondrial transplantation therapy (MTT) has 21 INFERRED edges - model-reasoned connections that need verification._
Mitochondria Transfer (e.g. with Mitochondrial transfer mechanism and MSC-EVs) actually correct?_Mitochondria Transfer has 9 INFERRED edges - model-reasoned connections that need verification._
Mitochondria (e.g. with Endurance Exercise and MitoCatch) actually correct?_Mitochondria has 3 INFERRED edges - model-reasoned connections that need verification._